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Curcumin Modulates 1,2-dibehenoyl-sn-glycero-3-phosphocholine (DBPC) Liposomes: Chitosan Oligosaccharide Lactate Influences Membrane Fluidity But Does Not Alter Phase Transition Temperature of DBPC Liposomes
- Source :
- Journal of Fluorescence. 32:155-163
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- 1,2-dibehenoyl-sn-glycero-3-phosphocholine (DBPC) is one of the important phospholipids found in cell membrane but not studied well. Importance of curcumin as a dietary supplement and for its medicinal properites is getting widely recoginsed. The present study for the first time explores the effect of curcumin on properties of DBPC liposomes by monitoring the fluorescence properties of curcumin. The phase transition temperature (Tm) of DBPC is assessed which confirms increase in curcumin concentration causes a slight drop in the Tm value. Chitosan is being applied for various drug delivery uses. The study establishes new insight on effect of chitosan oligosaccharide lactate on DBPC liposomes. It is found that in the absence of chitosan oligosaccharide lactate, curcumin partitions more strongly in the liquids crystalline phase than in the solid gel phase, however, the opposite result is obtained with the presence of chitosan oligosaccharide lactate which penetrates into the DBPC liposomes membranes at higher temperature, blocking thus the passage of curcumin into the lipid bilayer. However, addition of chitosan oligosaccharide lactate had no effect on the Tm. Fluorescence quenching study of curcumin establishes that the location of curcumin to be in the hydrophobic cavity of DBPC membrane.
- Subjects :
- Curcumin
Sociology and Political Science
Membrane permeability
Membrane Fluidity
Lipid Bilayers
Clinical Biochemistry
Oligosaccharides
Biochemistry
Fluorescence
Phase Transition
Chitosan
chemistry.chemical_compound
Drug Delivery Systems
Membrane fluidity
Transition Temperature
Lipid bilayer
Phospholipids
Spectroscopy
Liposome
Photochemical Processes
Liquid Crystals
Clinical Psychology
Membrane
chemistry
Liposomes
Drug delivery
Lactates
Biophysics
Hydrophobic and Hydrophilic Interactions
Law
Social Sciences (miscellaneous)
Subjects
Details
- ISSN :
- 15734994 and 10530509
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Fluorescence
- Accession number :
- edsair.doi.dedup.....c207b978ba037ec2215dd995225d733c