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Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats

Authors :
Salwa I. A. Wasfy
Hussein Ageely
Nasser S. Abou Khalil
Alaa Sayed Abou-Elhamd
Ibtisam M. H. El Mileegy
Mohamed Y. Hamed
Source :
Journal of Diabetes Research, Vol 2016 (2016), Journal of Diabetes Research
Publication Year :
2016
Publisher :
Hindawi Publishing Corporation, 2016.

Abstract

Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts ofBalanites aegyptiacaandPetroselinum sativumextracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancreas and the size of the islets of Langerhans and improvement in the histoarchitecture were evident in the treated groups compared to untreated ones. In conclusion, the present study provides a scientific evidence for the traditional use of these extracts as antidiabetic and antioxidant agents in type 1 diabetes mellitus.

Details

Language :
English
ISSN :
23146745
Database :
OpenAIRE
Journal :
Journal of Diabetes Research
Accession number :
edsair.doi.dedup.....c1e1b3101cbe85072a7188f7820e1440
Full Text :
https://doi.org/10.1155/2016/8408326