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Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats
- Source :
- Journal of Diabetes Research, Vol 2016 (2016), Journal of Diabetes Research
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts ofBalanites aegyptiacaandPetroselinum sativumextracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancreas and the size of the islets of Langerhans and improvement in the histoarchitecture were evident in the treated groups compared to untreated ones. In conclusion, the present study provides a scientific evidence for the traditional use of these extracts as antidiabetic and antioxidant agents in type 1 diabetes mellitus.
- Subjects :
- Blood Glucose
Male
0301 basic medicine
Antioxidant
Article Subject
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Antioxidants
Diabetes Mellitus, Experimental
law.invention
03 medical and health sciences
chemistry.chemical_compound
Endocrinology
law
Diabetes mellitus
Animals
Hypoglycemic Agents
Insulin
Medicine
Balanites
Rats, Wistar
Pancreas
Type 1 diabetes
Plants, Medicinal
lcsh:RC648-665
biology
Traditional medicine
Plant Extracts
business.industry
medicine.disease
biology.organism_classification
Malondialdehyde
Plant Leaves
Oxidative Stress
Diabetes Mellitus, Type 1
030104 developmental biology
chemistry
Fruit
Petroselinum
business
Phytotherapy
Biomarkers
Balanites aegyptiaca
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146745
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....c1e1b3101cbe85072a7188f7820e1440
- Full Text :
- https://doi.org/10.1155/2016/8408326