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Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women
Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women
- Source :
- Journal of Bone and Mineral Research. 11:1400-1405
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Calcium absorption declines with age. Because 1,25-dihydroxyvitamin D (1,25(OH)2D) is the major hormone controlling calcium absorption, changes in vitamin D metabolism may account for the malabsorption of aging. Serum levels of 1,25(OH)2D have been reported to either decrease or remain unchanged with age. To assess the effect of aging on renal production of 1,25(OH)2D, we evaluated the response of renal 25OHD 1 alpha hydroxylase to human parathyroid hormone (hPTH(1-34) stimulation in 119 women ages 25-83 years. In this population, baseline serum 25OHD and 1,25(OH)2D values did not significantly change with age, but serum iPTH (r = 0.44; p < 0.001) and serum creatinine (r = 0.31; p < 0.01) increased with age. However, the stimulatory activity of hPTH(1-34) on the renal production of 1,25(OH)2D declined with age (r3 = -0.36; p < 0.001) and was most apparent after age 75, being 50% less than that of younger women. Besides age, the production of 1,25(OH)2D was found to be dependent on baseline serum iPTH (r = -0.31; p < 0.0001). Administration of hPTH(1-34) led to suppression of endogenous PTH, and suppressibility of endogenous PTH declined with age (r = 0.53; p < 0.0001). The increase in serum PTH and decreased suppressibility of PTH with age could be due to mild secondary hyperparathyroidism. The increase in PTH with age is probably responsible for maintaining normal serum 1,25(OH)2D levels in elderly subjects; however, decreased metabolism of 1,25(OH)2D in the elderly could also maintain normal serum 1,25(OH)2D levels.
- Subjects :
- Adult
Aging
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Population
Parathyroid hormone
chemistry.chemical_compound
Calcitriol
Teriparatide
Internal medicine
medicine
Vitamin D and neurology
Humans
Orthopedics and Sports Medicine
Infusions, Intravenous
education
Infusion Pumps
Aged
Aged, 80 and over
Calcium metabolism
Analysis of Variance
Creatinine
education.field_of_study
business.industry
Blood Proteins
Middle Aged
medicine.disease
Steroid hormone
Endocrinology
chemistry
Parathyroid Hormone
Regression Analysis
Female
Secondary hyperparathyroidism
business
Hormone
Subjects
Details
- ISSN :
- 08840431
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Bone and Mineral Research
- Accession number :
- edsair.doi.dedup.....c1dbfa8a93a3bf394008cda26b8f51f2
- Full Text :
- https://doi.org/10.1002/jbmr.5650111005