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What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 3133, p 3133 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- One of the key features associated with the substantial increase in life expectancy for individuals with CF is an elevated predisposition to cancer, firmly established by recent studies involving large cohorts. With the recent advances in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and the increased long-term survival rate of individuals with cystic fibrosis (CF), this is a novel challenge emerging at the forefront of this disease. However, the mechanisms linking dysfunctional CFTR to carcinogenesis have yet to be unravelled. Clues to this challenging open question emerge from key findings in an increasing number of studies showing that CFTR plays a role in fundamental cellular processes such as foetal development, epithelial differentiation/polarization, and regeneration, as well as in epithelial–mesenchymal transition (EMT). Here, we provide state-of-the-art descriptions on the moonlight roles of CFTR in these processes, highlighting how they can contribute to novel therapeutic strategies. However, such roles are still largely unknown, so we need rapid progress in the elucidation of the underlying mechanisms to find the answers and thus tailor the most appropriate therapeutic approaches.
- Subjects :
- Epithelial-Mesenchymal Transition
Organogenesis
Cystic Fibrosis Transmembrane Conductance Regulator
wound healing
Review
Disease
Biology
medicine.disease_cause
Cystic fibrosis
Epithelium
Catalysis
Inorganic Chemistry
cystic fibrosis
lcsh:Chemistry
Epithelial Differentiation
epithelial regeneration
medicine
Animals
Homeostasis
Humans
Regeneration
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Regeneration (biology)
Organic Chemistry
Cancer
Cell Differentiation
General Medicine
medicine.disease
Key features
Cystic fibrosis transmembrane conductance regulator
epithelial differentiation
Computer Science Applications
Cell Transformation, Neoplastic
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Disease Susceptibility
Carcinogenesis
Neuroscience
carcinogenesis
epithelial–mesenchymal transition EMT
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 3133
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....c1d5e6b14bbaec51f31b66601f38b4a0