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Taenia solium Cysticercosis and Its Impact in Neurological Disease
- Source :
- Clin Microbiol Rev
- Publication Year :
- 2020
- Publisher :
- American Society for Microbiology, 2020.
-
Abstract
- Taenia solium neurocysticercosis (NCC) is endemic in most of the world and contributes significantly to the burden of epilepsy and other neurological morbidity. Also present in developed countries because of immigration and travel, NCC is one of few diseases targeted for eradication. This paper reviews all aspects of its life cycle (taeniasis, porcine cysticercosis, human cysticercosis), with a focus on recent advances in its diagnosis, management, and control. Diagnosis of taeniasis is limited by poor availability of immunological or molecular assays. Diagnosis of NCC rests on neuroimaging findings, supported by serological assays. The treatment of NCC should be approached in the context of the particular type of infection (intra- or extraparenchymal; number, location, and stage of lesions) and has evolved toward combined symptomatic and antiparasitic management, with particular attention to modulating inflammation. Research on NCC and particularly the use of recently available genome data and animal models of infection should help to elucidate mechanisms of brain inflammation, damage, and epileptogenesis.
- Subjects :
- Microbiology (medical)
Epidemiology
Swine
030231 tropical medicine
Neurocysticercosis
Context (language use)
Disease
Review
Epileptogenesis
03 medical and health sciences
Epilepsy
0302 clinical medicine
Taenia solium
parasitic diseases
Medicine
Taeniasis
Animals
Humans
Swine Diseases
General Immunology and Microbiology
Antiparasitic Agents
business.industry
urogenital system
Cysticercosis
Public Health, Environmental and Occupational Health
medicine.disease
medicine.drug_formulation_ingredient
Infectious Diseases
Immunology
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clin Microbiol Rev
- Accession number :
- edsair.doi.dedup.....c1d07d7b304a368688a19679bc39456e