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Treatment patterns and outcomes for patients with unresectable stage III and metastatic melanoma in the USA
- Source :
- Journal of Comparative Effectiveness Research. 8:461-473
- Publication Year :
- 2019
- Publisher :
- Becaris Publishing Limited, 2019.
-
Abstract
- Aim: To describe treatment patterns and outcomes of patients with unresectable stage III and metastatic/stage IV melanoma. Materials & methods: An observational retrospective chart review of patients diagnosed with advanced melanoma before 1 November 2015 who initiated a new line of therapy (LOT) from 1 January 2015 to 31 May 2016. Results: Among 487 patients, ipilimumab monotherapy (27.5%) was the most common first line of therapy (1LOT) in 2015, surpassed by nivolumab monotherapy (21.5%) in 2016. 12-month survival was ≥80.1%; proportions were highest forpatients treated with nivolumab + ipilimumab (86.6%). All treatments relatively well tolerated in real-world setting and adverse events were consistent with the previously reported safety profiles. Conclusion: This study provides important insights into real-world advanced melanoma treatment patterns and demonstrates encouraging treatment safety and patient survival data.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Metastatic melanoma
Line of therapy
Ipilimumab
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
030212 general & internal medicine
Progression-free survival
Neoplasm Metastasis
Stage (cooking)
Adverse effect
Melanoma
Aged
Neoplasm Staging
Retrospective Studies
business.industry
Health Policy
Middle Aged
United States
Nivolumab
030220 oncology & carcinogenesis
Female
Observational study
business
medicine.drug
Subjects
Details
- ISSN :
- 20426313 and 20426305
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Comparative Effectiveness Research
- Accession number :
- edsair.doi.dedup.....c1cca5ad3dd065ac0846b851ebbd38a9