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Morphological Analysis of Spherical Adsorptive Carbon Granules Using Three-Dimensional X-Ray Micro-computed Tomography

Authors :
Ken-ichi Izutsu
Chikako Yomota
Yasuhiro Abe
Hiroyuki Yoshida
Source :
Chemical and Pharmaceutical Bulletin. 68:179-180
Publication Year :
2020
Publisher :
Pharmaceutical Society of Japan, 2020.

Abstract

The purpose of this study was to clarify applicability of three-dimensional X-ray micro-computed tomography (3D X-ray micro-CT) to elucidate interior morphology of spherical adsorptive carbon fine granules. Scanning of small single spherical granule hold on the rotating sample stage provided the structural information without particular preparation (e.g., slicing) that can affect the definite morphology. The three model formulations with similar appearance showed different internal structure in the 3D images, including large hollow in one of them. Other formulations showed some small empty or higher density area in the filled granules, suggesting uneven distribution of carbon. The results indicated relevance of the X-ray micro-CT analysis on the physical characterization of the spherical adsorptive carbon granule formulations.

Details

ISSN :
13475223 and 00092363
Volume :
68
Database :
OpenAIRE
Journal :
Chemical and Pharmaceutical Bulletin
Accession number :
edsair.doi.dedup.....c1ca6fcbf49c9a1344e080219f35abf5
Full Text :
https://doi.org/10.1248/cpb.c19-00732