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Morphological Analysis of Spherical Adsorptive Carbon Granules Using Three-Dimensional X-Ray Micro-computed Tomography
- Source :
- Chemical and Pharmaceutical Bulletin. 68:179-180
- Publication Year :
- 2020
- Publisher :
- Pharmaceutical Society of Japan, 2020.
-
Abstract
- The purpose of this study was to clarify applicability of three-dimensional X-ray micro-computed tomography (3D X-ray micro-CT) to elucidate interior morphology of spherical adsorptive carbon fine granules. Scanning of small single spherical granule hold on the rotating sample stage provided the structural information without particular preparation (e.g., slicing) that can affect the definite morphology. The three model formulations with similar appearance showed different internal structure in the 3D images, including large hollow in one of them. Other formulations showed some small empty or higher density area in the filled granules, suggesting uneven distribution of carbon. The results indicated relevance of the X-ray micro-CT analysis on the physical characterization of the spherical adsorptive carbon granule formulations.
- Subjects :
- Spherical granule
Chemistry
Drug Compounding
Micro computed tomography
Granule (cell biology)
X-ray
X-Ray Microtomography
General Chemistry
General Medicine
Carbon
law.invention
Imaging, Three-Dimensional
Magazine
law
Drug Discovery
Morphological analysis
Adsorption
Tomography
Particle Size
Composite material
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....c1ca6fcbf49c9a1344e080219f35abf5
- Full Text :
- https://doi.org/10.1248/cpb.c19-00732