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Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat
- Source :
- Neuroscience Letters. 211:57-60
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk B mRNA, in brain. In situ hybridization studies showed that BDNF and trk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemic MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct which could survive.
- Subjects :
- Male
medicine.medical_specialty
Cerebral arteries
Ischemia
In situ hybridization
Hippocampus
Brain Ischemia
Rats, Sprague-Dawley
Neurotrophic factors
Internal medicine
medicine.artery
Cortex (anatomy)
medicine
Animals
RNA, Messenger
cardiovascular diseases
Receptor
In Situ Hybridization
Cerebral Cortex
Brain-derived neurotrophic factor
business.industry
Brain-Derived Neurotrophic Factor
General Neuroscience
Receptor Protein-Tyrosine Kinases
medicine.disease
Rats
nervous system diseases
Endocrinology
medicine.anatomical_structure
Gene Expression Regulation
nervous system
Middle cerebral artery
cardiovascular system
Autoradiography
business
Neuroscience
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....c1c5a454c998f91e6efa6f6cf96c28fa