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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators
- Source :
- Bioorganicmedicinal chemistry letters. 18(20)
- Publication Year :
- 2008
-
Abstract
- The synthesis and structure–activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identification of potent, metabolically stable and orally available mGluR2 positive allosteric modulators (PAMs).
- Subjects :
- Stereochemistry
Chemistry, Pharmaceutical
Clinical Biochemistry
Allosteric regulation
Drug Evaluation, Preclinical
Pharmaceutical Science
Administration, Oral
Receptors, Metabotropic Glutamate
Biochemistry
Chemical synthesis
Structure-Activity Relationship
Allosteric Regulation
Microsomes
Drug Discovery
Animals
Humans
Molecular Biology
Bicyclic molecule
Chemistry
Ligand
Organic Chemistry
Metabolic stability
Rats
Models, Chemical
Drug Design
Benzene derivatives
Schizophrenia
Molecular Medicine
Benzimidazoles
Metabotropic glutamate receptor 2
Azabicyclo Compounds
Allosteric Site
Ethers
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 18
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....c1c2926e12cc5a6c438c63b040f7e927