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Vascular changes in diabetic retinopathy—a longitudinal study in the Nile rat
- Source :
- Laboratory investigation; a journal of technical methods and pathology, vol 99, iss 10, Laboratory investigation; a journal of technical methods and pathology
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics of retinal cellular changes in the Nile rat (Arvicanthis niloticus), a carbohydrate-sensitive model for type 2 diabetes. The early retinal changes in diabetic Nile rats included increased acellular capillaries and loss of pericytes that correlated linearly with the duration of diabetes. These vascular changes occurred in the presence of microglial infiltration but in the absence of retinal ganglion cell loss. After a prolonged duration of diabetes, the Nile rat also exhibits a spectrum of retinal lesions commonly seen in the human condition including vascular leakage, capillary non-perfusion, and neovascularization. Our longitudinal study documents a range and progression of retinal lesions in the diabetic Nile rat remarkably similar to those observed in human diabetic retinopathy, and suggests that this model will be valuable in identifying new therapeutic strategies.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Clinical Sciences
Disease
Type 2 diabetes
Article
Retina
Pathology and Forensic Medicine
Neovascularization
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Diabetes mellitus
medicine
Animals
Edema
Longitudinal Studies
Molecular Biology
Diabetic Retinopathy
business.industry
Retinal
Cell Biology
Diabetic retinopathy
medicine.disease
Capillaries
3. Good health
030104 developmental biology
medicine.anatomical_structure
Retinal ganglion cell
chemistry
030220 oncology & carcinogenesis
Disease Progression
Murinae
medicine.symptom
business
Subjects
Details
- ISSN :
- 00236837
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Laboratory Investigation
- Accession number :
- edsair.doi.dedup.....c1c26cad1e597cb66d15d25520dc3e97