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Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats
- Source :
- Journal of Hypertension
- Publication Year :
- 2021
- Publisher :
- Lippincott Williams & Wilkins, 2021.
-
Abstract
- Background Central arterial stiffness (CAS) is associated with elevated arterial blood pressure (BP) and is likely associated with stiffening of cerebral artery walls, with attendant cerebral hypoperfusion, neuronal density loss and cognitive decline. Dahl salt-sensitive (Dahl-S) rats exhibit age-associated hypertension and memory loss, even on a normal salt intake.Method: We sought to explore whether central arterial pulse wave velocity (PWV), a marker of CAS, is associated with hippocampal cerebral blood flow (CBF) and neuronal density in hypertensive Dahl-S rats. We measured systolic BP (by tail-cuff plethysmography), aortic PWV (by echocardiography) and CBF and N-acetyl aspartate (NAA) (by magnetic resonance imaging) in 6 month-old male Dahl-S rats (n = 12). Results Greater PWV was significantly associated with lower CBF and lower NAA concentration in the hippocampus, supporting a role of CAS in cerebrovascular dysfunction and decline in cognitive performance with aging. Conclusion These findings implicate increased CAS in cerebral hypoperfusion and loss of neuronal density and function in the Dahl-S model of age-associated cardiovascular dysfunction.
- Subjects :
- Male
medicine.medical_specialty
hypertension
N-acetyl aspartate
Physiology
hippocampus
ORIGINAL PAPERS: Basic science
brain metabolites
pulse wave velocity
Cerebral arteries
cerebral blood flow
Blood Pressure
Pulse Wave Analysis
Vascular Stiffness
Internal medicine
neuronal density
Internal Medicine
medicine
Hippocampus (mythology)
Plethysmograph
magnetic resonance imaging
Animals
cardiovascular diseases
Cognitive decline
Dahl salt-sensitive rats
Aspartic Acid
Rats, Inbred Dahl
business.industry
aging
arterial blood pressure
Blood flow
medicine.disease
Rats
Blood pressure
arterial stiffness
Cerebral blood flow
nervous system
Arterial stiffness
Cardiology
cardiovascular system
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 14735598 and 02636352
- Volume :
- 39
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Hypertension
- Accession number :
- edsair.doi.dedup.....c1affed36d89608669f4a6fdea2d6ac3