Back to Search
Start Over
pH-responsive mesoporous silica drug delivery system for targeted cancer chemotherapy
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis, 2020.
-
Abstract
- In this paper, a kind of pH-responsive mesoporous silica targeted drug delivery system (DOX-loaded N-CQDs/HA gated pSiO2/MPEG-Glu) was designed and synthesised. In this system, active mesoporous silica (pSiO2) worked as a carrier material, methoxy polyethene glycol amine (MPEG) and L-glutamic acid (Glu) can be coupled and grafted to the surface of the pSiO2 drug carrier to improve the stability of the drug delivery system, nitrogen-doped carbon quantum dots (N-CQDs) and hyaluronic acid (HA) can inhibit the rapid release of drug. Ultraviolet (UV-Vis) spectrum showed that the drug-loading rate of DOX is 8.9%, the drug release in vitro study suggested that the prepared silica drug delivery system had significant pH-responsive and targeted DOX release, the drug release rate is 55.7% at pH = 5.0, which was much higher than the release of pH = 7.4; CLSM and MTT showed that the drug delivery system can enter into cancer cells through endocytosis and the DOX can act on cell nucleus, exhibiting a targeted therapy on cancer cells.
- Subjects :
- Cancer chemotherapy
Chemistry
Mechanical Engineering
medicine.medical_treatment
Nanotechnology
02 engineering and technology
Mesoporous silica
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
Targeted therapy
Targeted drug delivery
Mechanics of Materials
Drug delivery
medicine
General Materials Science
0210 nano-technology
Mesoporous material
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c1adfa85da2dc9b4e461d845f01276ba
- Full Text :
- https://doi.org/10.6084/m9.figshare.12204800