Additional file 1: of Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Figures S1 through S10. Figure S1. Transcript expression of Tmem106b in Tmem106b deficiency mice at different ages. Figure S2. Tmem106b reduction does not alter the expression of its family members. Figure S3. Tmem106b immunoreactivity in mice with Tmem106b gene interruption using an additional antibody. Figure S4. The body weight of 2R and 66R injected mouse. Figure S5. Tmem106b reduction alone induces astrogliosis. Figure S6. Heterozygous loss of Tmem106b partially rescues 66R injection-induced neuronal loss. Figure S7. pTdp-43 immunoreactivity in 2R and 66R injected mouse brain. Figure S8. Endogenous C9orf72 protein levels in 2R- and 66R-injected mouse brain. Figure S9. Validation of (GGGGCC)66 repeat overexpression and C9ORF72 knockdown. Figure S10. The effect of (GGGGCC)66 overexpression or C9ORF72 knockdown on TMEM106B protein levels in U251 cells. (DOCX 26231 kb)