Back to Search
Start Over
Serum iron concentration in cattle with endotoxaemia
- Source :
- Acta Veterinaria Hungarica. 68:53-58
- Publication Year :
- 2020
- Publisher :
- Akademiai Kiado Zrt., 2020.
-
Abstract
- The objective of this study was to examine whether serum iron (Fe) concentration is useful as a prognostic biomarker for cows with acute coliform mastitis (ACM). Our study was composed of determining the reproducibility of serum Fe concentration as a prognostic criterion in cows with ACM (Study 1) and clarifying the sequential changes in serum Fe concentration in cattle that received endotoxin (Study 2). Seventy-seven cows with (n = 47) or without (n = 30) ACM were enrolled in Study 1. The proposed diagnostic cut-off value of serum Fe concentration indicating a poor prognosis of ACM based on the analysis of the receiver operating characteristic curves was < 31.5 µg/dL. Ten young cattle aged 176.8 ± 23.7 days were enrolled in Study 2. Five young cattle received endotoxin (LPS group) and the remaining five received physiological saline (control group). Blood collections were carried out before endotoxin challenge (pre), and 0.5, 1, 2, 4, 8, 12, 24, and 48 h after the challenge. As a result, a significant decrease in serum Fe concentration was not observed until 24 h after endotoxin challenge. Because in cows with clinical ACM it is difficult to know the time course after infection, the alteration in serum Fe concentrations alone may be an insufficient prognostic criterion.
- Subjects :
- medicine.medical_specialty
Poor prognosis
040301 veterinary sciences
Iron
Gastroenterology
Endotoxin challenge
030308 mycology & parasitology
0403 veterinary science
03 medical and health sciences
Internal medicine
Escherichia coli
medicine
Animals
Prognostic biomarker
Coliform mastitis
Mastitis, Bovine
Physiological saline
Escherichia coli Infections
0303 health sciences
General Veterinary
medicine.diagnostic_test
business.industry
Reproducibility of Results
04 agricultural and veterinary sciences
Prognosis
Endotoxemia
Klebsiella Infections
Endotoxins
Klebsiella pneumoniae
Acute Disease
Time course
Serum iron
Cattle
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 15882705 and 02366290
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Acta Veterinaria Hungarica
- Accession number :
- edsair.doi.dedup.....c1960b559261efc6f3ad4592b8a6bf77