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A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results
- Source :
- European radiology. 28(1)
- Publication Year :
- 2016
-
Abstract
- To evaluate the applicability of a semiquantitative MRI scoring system (MR-CF-S) as a prognostic marker for clinical course of cystic fibrosis (CF) lung disease. This observational study of a single-centre CF cohort included a group of 61 patients (mean age 12.9 ± 4.7 years) receiving morphological and functional pulmonary MRI, pulmonary function testing (PFT) and follow-up of 2 years. MRI was analysed by three raters using MR-CF-S. The inter-rater agreement, correlation of score categories with forced expiratory volume in 1 s (FEV1) at baseline, and the predictive value of clinical parameters, and score categories was assessed for the whole cohort and a subgroup of 40 patients with moderately impaired lung function. The inter-rater agreement of MR-CF-S was sufficient (mean intraclass correlation coefficient 0.92). MR-CF-S (−0.62; p 3%/year) and normal course were only significant for MR-CF-S (p
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Cystic Fibrosis
Intraclass correlation
Cystic fibrosis
030218 nuclear medicine & medical imaging
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
Forced Expiratory Volume
medicine
Humans
Radiology, Nuclear Medicine and imaging
Child
Lung
Neuroradiology
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
medicine.disease
Magnetic Resonance Imaging
Respiratory Function Tests
medicine.anatomical_structure
030228 respiratory system
ROC Curve
Cohort
Observational study
Female
Radiology
business
Subjects
Details
- ISSN :
- 14321084
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....c1948834a5ab97b7971113d731640adc