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Markers of adiposity, insulin resistance, prediabetes and cognitive function at baseline of the Brazilian Longitudinal Study of Adult Health (ELSA - Brasil)
- Source :
- Diabetes research and clinical practice. 170
- Publication Year :
- 2020
-
Abstract
- Aim The aim of the study is to investigate whether adiposity markers, insulin resistance and prediabetes are associated with cognitive performance in middle-aged men and women without diabetes. Methods Cross-sectional study with 11,115 adults without diabetes (34–64 years old). Cognitive performance was tested by word-list learning, word-list delayed recall, word recognition tests, semantic and phonemic verbal fluency tests and trail making test B. Linear regression models and generalized linear regression with logarithmic links between the cognitive tests and anthropometric indicators (body mass index [BMI]), insulin resistance (Homeostasis Model Assessment for Insulin Resistance [HOMA-IR]), and prediabetes (impaired glucose tolerance) were stratified by sex. The results were adjusted for age, education, comorbidities, health-related behaviors, waist circumference, and lipids. Results Among women, higher BMI was associated with poorer performance on phonemic verbal fluency test (β-0.02 [−0.04; −0.01]) and memory tests (β-0.05 [−0.07; −0.02]). Higher HOMA-IR was associated with poorer cognitive performance in memory (β-0.11 [−0.19; −0.01]) and phonemic verbal fluency tests (β-0.12 [−0.20; −0.04]). In men, HOMA-IR (β-0.15 [−0.25; −0.04]) and prediabetes (β-0.35 [−0.69; -0.03]) were associated with poorer performance on memory tests. Conclusions We found a significant association of BMI and HOMA-IR with cognitive performance in young and middle-aged adult women without diabetes. In men, we found an association between HOMA-IR and prediabetes and poorer performance on memory tests.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Trail Making Test
030209 endocrinology & metabolism
Impaired glucose tolerance
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
Cognition
Internal medicine
Internal Medicine
medicine
Verbal fluency test
Humans
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Prediabetes
Longitudinal Studies
Adiposity
business.industry
General Medicine
medicine.disease
Cognitive test
Cross-Sectional Studies
Female
Insulin Resistance
business
Body mass index
Brazil
Subjects
Details
- ISSN :
- 18728227
- Volume :
- 170
- Database :
- OpenAIRE
- Journal :
- Diabetes research and clinical practice
- Accession number :
- edsair.doi.dedup.....c19030655fc2c2ddac98f4b16165817c