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A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis, 2020.
-
Abstract
- Citrus fruits are rich sources of bioactive compounds and their consumption is associated to health-promoting effects. Citrus processing wastes contain bioflavonoids and other high added value compounds. The aim of this study was to evaluate the antiallergic properties of a new phytoextract obtained by citrus wastes and peels. Blood orange and lemon processing wastes were used to produce a Red orange and Lemon Extract (RLE). Blood samples from 30 allergic donors were collected and used to evaluate the basophil activation (CD203c) and degranulation (CD63) by stimulation trough allergen with and without the RLE. Reduced basophil expression of CD203c and CD63 were observed in RLE + Allergen treated samples, with -20.21% of CD203c expression (p < 0.0001) and -54.11% of CD63 expression (p < 0.0001), compared to Allergen treated samples. The RLE evidenced a good antiallergic activity, mainly acting on basophils degranulation, and therefore reducing the key event of pro-inflammatory mediators release after allergic stimuli.
- Subjects :
- Citrus
lemon
Basophil Degranulation Test
Plant Science
Orange (colour)
Basophil
Basophil degranulation
medicine.disease_cause
01 natural sciences
Biochemistry
Analytical Chemistry
antiallergic, CD203c, Citrus fruit
Allergen
CD63
medicine
Food science
Plant Extracts
Tetraspanin 30
010405 organic chemistry
Chemistry
Organic Chemistry
Degranulation
Red Orange
food and beverages
Flow Cytometry
Lemon extract
Basophils
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Basophil activation
medicine.anatomical_structure
Citrus fruit
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c17ed677f3afc87d7df33732594d31d0
- Full Text :
- https://doi.org/10.6084/m9.figshare.12258206.v1