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Increased transcapillary escape rate of albumin and IgG in essential hypertension
- Source :
- Scandinavian Journal of Clinical and Laboratory Investigation. 37:223-227
- Publication Year :
- 1977
- Publisher :
- Informa UK Limited, 1977.
-
Abstract
- Transcapillary escape rates of albumin and IgG (fractions of intravascular mass of albumin and IgG that pass to the extravascular space per unit time) were determined simultaneously from the initial disappearance of intravenously injected 131I human albumin and 125I human IgG in seven untreated subjects suffering from essential hypertension. The average mean arterial blood pressure of these subjects 193/119 mmHg; four subjects had grade I-III funduscopic changes. Transcapillary escape rates of albumin (TERalb) and IgG (TERIgG) were found significantly increased in the hypertensive subjects, average 7.8 +/- 0.9 (SD) and 4.7 +/- 1.0 (SD) %/h, respectively, compared with normal values of mean 5.2 +/- 1.0 (SD) and 3.0 +/- 0.7 (SD) %/h, respectively (P less than 0.01). There was a statistically significant positive correlation between the mean arterial blood pressure and TER of albumin and of IgG (P less than 0.001). The TERIgG/TERalb ratio was about the same in the hypertensives and the normals. Confirming a previous observation, we found an increase in the daily urinary albumin excretion rate from a normal average of 9.1 (range, 2.4-20.4)mg/24 h to 96 (range, 5.6-565) mg/24 h, P less than 0.05. The present findings can best be explained by increased filtration through normal pores between the endothelial cells in the microvasculature, due to the high arterial blood pressure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Clinical Biochemistry
Blood Pressure
Vascular permeability
Normal values
Essential hypertension
Capillary Permeability
Internal medicine
medicine
Humans
Escape rate
Serum Albumin
Chemistry
Albumin
Human albumin
General Medicine
Middle Aged
medicine.disease
Endocrinology
Blood pressure
Immunoglobulin G
Hypertension
Injections, Intravenous
Immunology
Significant positive correlation
Subjects
Details
- ISSN :
- 15027686 and 00365513
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Clinical and Laboratory Investigation
- Accession number :
- edsair.doi.dedup.....c17df48137a296d8946bcc22b95ed190