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FeCl3-Catalyzed Addition of 1,3-Dicarbonyl Compounds to Aromatic Olefins
- Source :
- ChemInform. 38
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- A direct, intermolecular addition of 1,3-dicarbonyl compounds to styrenes in the presence of FeCl3 as an inexpensive and disposable catalyst has been developed for the straightforward and practical synthesis of arylated diketones and ketoesters. The reactions proceed under mild conditions for most substrates (50-80 degrees C), and no strong acid or base is required. The synthetic value of the method is demonstrated by 15 examples, including the synthesis of the current pharmaceutical drug warfarin in one step and 42% yield from commercially available substrates.
- Subjects :
- chemistry.chemical_classification
Pharmaceutical drug
Addition reaction
Base (chemistry)
medicine.medical_treatment
Organic Chemistry
Intermolecular force
One-Step
General Chemistry
General Medicine
Biochemistry
Combinatorial chemistry
Styrene
Catalysis
C c coupling
chemistry.chemical_compound
chemistry
Yield (chemistry)
medicine
Organic chemistry
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....c16e99fa4b6e2ecd959338d58218fce8