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Two Genotypes of Coxsackievirus A2 Associated with Hand, Foot, and Mouth Disease Circulating in China since 2008
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 12, p e0169021 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- Coxsackievirus A2 (CV-A2) has been frequently detected and commonly associated with hand, foot, and mouth disease (HFMD) in China since 2008. However, limited sequences of CV-A2 are currently available. As a result, we have been focusing on the genetic characteristics of CV-A2 in the mainland of China during 2008-2015 based on national HFMD surveillance. In this study, 20 CV-A2 strains were isolated and phylogenetic analyses of the VP1 sequences were performed. Full-length genome sequences of two representative CV-A2 isolates were acquired and similarity plot and bootscanning analyses were performed. The phylogenetic dendrogram indicated that all CV-A2 strains could be divided into four genotypes (Genotypes A-D). The CV-A2 prototype strain (Fleetwood) was the sole member of genotype A. From 2008 to 2015, the CV-A2 strains isolated in China dispersed into two different genotypes (B and D). And the genotype D became the dominant circulating strains in China. Strains isolated in Russia and India from 2005 to 2011 converged into genotype C. Intertypic recombination occurred between the Chinese CV-A2 strains and other enterovirus-A donor sequences. This result reconfirmed that recombination is a common phenomenon among enteroviruses. This study helps expand the numbers of whole virus genome sequence and entire VP1 sequence of CV-A2 in the GenBank database for further researcher.
- Subjects :
- 0301 basic medicine
Viral Diseases
Time Factors
lcsh:Medicine
Geographical Locations
Genotype
Medicine and Health Sciences
lcsh:Science
Phylogeny
Genetics
Multidisciplinary
Foot-and-mouth disease
biology
Phylogenetic tree
Database and informatics methods
Sequence analysis
Phylogenetic Analysis
Infectious Diseases
GenBank
Engineering and Technology
Research Article
China
Asia
Bioinformatics
030106 microbiology
Nucleotide Sequencing
Sequence Databases
Coxsackievirus
03 medical and health sciences
Phylogenetics
medicine
Enterovirus Infections
Prototypes
Humans
Molecular Biology Techniques
Sequencing Techniques
Molecular Biology
DNA sequence analysis
Whole genome sequencing
Molecular Biology Assays and Analysis Techniques
lcsh:R
Biology and Life Sciences
medicine.disease
biology.organism_classification
Virology
Enterovirus A, Human
Research and analysis methods
030104 developmental biology
Biological Databases
Technology Development
People and Places
DNA, Viral
lcsh:Q
Hand, Foot and Mouth Disease
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c1650f0be79b8b037bd7f728702b4e89