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Dopamine D2 receptor availability is linked to hippocampal-caudate functional connectivity and episodic memory
- Source :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Year :
- 2016
-
Abstract
- D1 and D2 dopamine receptors (D1DRs and D2DRs) may contribute differently to various aspects of memory and cognition. The D1DR system has been linked to functions supported by the prefrontal cortex. By contrast, the role of the D2DR system is less clear, although it has been hypothesized that D2DRs make a specific contribution to hippocampus-based cognitive functions. Here we present results from 181 healthy adults between 64 and 68 y of age who underwent comprehensive assessment of episodic memory, working memory, and processing speed, along with MRI and D2DR assessment with [(11)C]raclopride and PET. Caudate D2DR availability was positively associated with episodic memory but not with working memory or speed. Whole-brain analyses further revealed a relation between hippocampal D2DR availability and episodic memory. Hippocampal and caudate D2DR availability were interrelated, and functional MRI-based resting-state functional connectivity between the ventral caudate and medial temporal cortex increased as a function of caudate D2DR availability. Collectively, these findings indicate that D2DRs make a specific contribution to hippocampus-based cognition by influencing striatal and hippocampal regions, and their interactions.
- Subjects :
- Male
0301 basic medicine
Age-Related-Changes
Memory, Episodic
Dopamine
Medial Temporal-Lobe
Caudate nucleus
Prefrontal Cortex
Positron-Emission-Tomography
Hippocampus
Spatial memory
03 medical and health sciences
Cognition
0302 clinical medicine
Memory
Working-Memory
Dopamine receptor D2
Individual-Differences
Humans
Long-Term-Memory
Prefrontal cortex
Episodic memory
Aged
Alzheimers-Disease
Multidisciplinary
Receptors, Dopamine D2
Working memory
Long-term memory
Cognitive Performance
Middle Aged
Biological Sciences
Neuroanatomy of memory
Human-Brain
030104 developmental biology
Female
Caudate Nucleus
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....c15765163eba9b0efb9079b973278de4