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Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress
- Source :
- BMC Gastroenterology, Vol 12, Iss 1, p 54 (2012), BMC Gastroenterology
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Background This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS). Methods Sixty male Sprague–Dawley rats (200-250 g) were randomly divided into three equal sized groups. The control group was given a normal diet, while the treated groups received the same diet with oral supplementation of PVE or α-TF at 60 mg/kg body weight. After the treatment period of 28 days, each group was further subdivided into two groups with 10 rats without exposing them to stress and the other 10 rats were subjected to WIRS for 3.5 hours. Blood samples were taken to measure the adrenalin and noradrenalin levels. The rats were then sacrificed following which the stomach was excised and opened along the greater curvature and examined for lesions and XO + XD activities. Results The rats exposed to WIRS had lesions in their stomach mucosa. Our findings showed that dietary supplementations of PVE and α-TF were able to reduce gastric lesions significantly in comparison to the stressed control group. WIRS increased plasma adrenalin and noradrenalin significantly. PVE and α-TF treatments reduced these parameters significantly compared to the stressed control. Conclusions Supplementations with either PVE or α-TF reduce the formation of gastric lesions. Their protective effect was related to their abilities to inhibit stress induced elevation of adrenalin and noradrenalin levels as well as through reduction in xanthine oxidase and dehydrogenase activities.
- Subjects :
- Male
Xanthine Oxidase
medicine.medical_specialty
Epinephrine
Normal diet
medicine.medical_treatment
alpha-Tocopherol
Stomach Diseases
Dehydrogenase
Rats, Sprague-Dawley
Norepinephrine
chemistry.chemical_compound
Catecholamines
Stress, Physiological
Internal medicine
Immersion
medicine
Animals
Vitamin E
lcsh:RC799-869
Xanthine oxidase
business.industry
Stomach
Gastroenterology
General Medicine
Curvatures of the stomach
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Gastric Mucosa
Dietary Supplements
Models, Animal
lcsh:Diseases of the digestive system. Gastroenterology
Oxidoreductases
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 1471230X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- BMC Gastroenterology
- Accession number :
- edsair.doi.dedup.....c1528c2d4d11d5041d0b99389e05a43e