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Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model
- Source :
- Nanomedicine: Nanotechnology, Biology and Medicine, Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2018, 14 (2), pp.609-618. ⟨10.1016/j.nano.2017.12.006⟩
- Publication Year :
- 2017
-
Abstract
- Alzheimer's disease (AD) is a neurodegenerative disorder related, in part, to the accumulation of amyloid-β peptide (Aβ) and especially the Aβ peptide 1-42 (Aβ1-42). The aim of this study was to design nanocarriers able to: (i) interact with the Aβ1-42 in the blood and promote its elimination through the “sink effect” and (ii) correct the memory defect observed in AD-like transgenic mice. To do so, biodegradable, PEGylated nanoparticles were surface-functionalized with an antibody directed against Aβ1-42. Treatment of AD-like transgenic mice with anti-Aβ1-42-functionalized nanoparticles led to: (i) complete correction of the memory defect; (ii) significant reduction of the Aβ soluble peptide and its oligomer level in the brain and (iii) significant increase of the Aβ levels in plasma. This study represents the first example of Aβ1-42 monoclonal antibody-decorated nanoparticle-based therapy against AD leading to complete correction of the memory defect in an experimental model of AD.
- Subjects :
- Male
Polymers
Pharmaceutical Science
Medicine (miscellaneous)
Peptide
02 engineering and technology
Oligomer
chemistry.chemical_compound
Mice
0302 clinical medicine
General Materials Science
ComputingMilieux_MISCELLANEOUS
Blood-brain barrier
chemistry.chemical_classification
biology
Chemistry
nanoparticle
Antibodies, Monoclonal
Alzheimer's disease
021001 nanoscience & nanotechnology
nanomedicine
Cell biology
medicine.anatomical_structure
Monoclonal
Molecular Medicine
Antibody
Polymer nanoparticle
0210 nano-technology
Genetically modified mouse
brain
Biomedical Engineering
Bioengineering
Mice, Transgenic
Blood–brain barrier
03 medical and health sciences
β-Amyloid peptide
Alzheimer Disease
medicine
Animals
Humans
Memory Disorders
Amyloid beta-Peptides
Recovery of Function
medicine.disease
Disease Models, Animal
[CHIM.POLY]Chemical Sciences/Polymers
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
biology.protein
Nanoparticles
Nanocarriers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15499642 and 15499634
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Accession number :
- edsair.doi.dedup.....c14f6ddacd39333a1d8e4df7e4ed1dcf