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Parasitic modulation of host development by ubiquitin-independent protein degradation
- Source :
- Cell, 184(20), 5201-5214.e12, Cell 184 (2021) 20, Cell, Cell, 2021, 184 (20), pp.5201-5214.e12. ⟨10.1016/j.cell.2021.08.029⟩
- Publication Year :
- 2021
-
Abstract
- International audience; Certain obligate parasites induce complex and substantial phenotypic changes in their hosts in ways that favor their transmission to other trophic levels. However, the mechanisms underlying these changes remain largely unknown. Here we demonstrate how SAP05 protein effectors from insect-vectored plant pathogenic phytoplasmas take control of several plant developmental processes. These effectors simultaneously prolong the host lifespan and induce witches' broom-like proliferations of leaf and sterile shoots, organs colonized by phytoplasmas and vectors, SAP05 acts by mediating the concurrent degradation of SPL and GATA developmental regulators via a process that relies on hijacking the plant ubiquitin receptor RPN10 independent of substrate ubiquitination. RPN10 is highly conserved among eukaryotes, but SAP05 does not bind insect vector RPN10. A two-amino-acid substitution within plant RPN10 generates a functional variant that is resistant to SAP05 activities. Therefore, one effector protein enables obligate parasitic phytoplasmas to induce a plethora of developmental phenotypes in their hosts.
- Subjects :
- Insecta
Transcription, Genetic
Arabidopsis
phloem
Ubiquitin
developmental phase transition
Phylogeny
Protein Stability
Effector
Reproduction
Plants, Genetically Modified
Phenotype
plant pathogen
Cell biology
Laboratory of Molecular Biology
Genetic Engineering
Plant Shoots
zombie plant
Proteasome Endopeptidase Complex
vasculature-colonizing bacteria
Phytoplasma
Photoperiod
Plant Development
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Protein degradation
Biology
Models, Biological
non-culturable bacteria
General Biochemistry, Genetics and Molecular Biology
Host-Parasite Interactions
Tobacco
Animals
Humans
Laboratorium voor Moleculaire Biologie
Parasites
Amino Acid Sequence
BIOS Plant Development Systems
mycoplasma
Ubiquitins
Obligate
Arabidopsis Proteins
Host (biology)
fungi
insect vectors
Obligate parasite
Proteasome
Proteolysis
biology.protein
ubiquitin-proteasome system
targeted protein degradation
Transcription Factors
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 00928674 and 10974172
- Database :
- OpenAIRE
- Journal :
- Cell, 184(20), 5201-5214.e12, Cell 184 (2021) 20, Cell, Cell, 2021, 184 (20), pp.5201-5214.e12. ⟨10.1016/j.cell.2021.08.029⟩
- Accession number :
- edsair.doi.dedup.....c145dcb108ab1a69432c9b28f9f26377