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Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure
- Source :
- European journal of heart failure. 9(3)
- Publication Year :
- 2005
-
Abstract
- Background: Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction. Aims: We postulated that ascorbic acid would improve oxygen delivery to exercising muscle and improve skeletal muscle metabolism. Methods: We studied skeletal muscle metabolism using 31P magnetic resonance spectroscopy in 39 CHF patients. Endothelial function was assessed by changes in pulse wave velocity. Subjects were randomised to receive 4g ascorbic acid daily for 4weeks in a placebo-controlled double-blind study. Results: Ascorbic acid significantly increased phosphocreatine utilization during exercise. In addition, glycolytic ATP synthesis increased in the ascorbic acid group (change in rate of ATP synthesis at 1min −0.21±0.76 with placebo, 2.06±0.60 following ascorbic acid; p
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Phosphocreatine
Ascorbic Acid
chemistry.chemical_compound
Hyperaemia
Adenosine Triphosphate
Double-Blind Method
Internal medicine
medicine
Humans
Glycolysis
Endothelial dysfunction
Muscle, Skeletal
Aged
Heart Failure
business.industry
Skeletal muscle
Metabolism
Middle Aged
Ascorbic acid
medicine.disease
United Kingdom
medicine.anatomical_structure
Endocrinology
chemistry
Heart failure
Chronic Disease
Female
Endothelium, Vascular
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13889842
- Volume :
- 9
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of heart failure
- Accession number :
- edsair.doi.dedup.....c145771f782384e52727a0efe12bddfb