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Preservation of antimyosin antibody activity after covalent coupling to liposomes
- Source :
- Biochemical and Biophysical Research Communications. 89:1114-1119
- Publication Year :
- 1979
- Publisher :
- Elsevier BV, 1979.
-
Abstract
- A procedure for coupling liposomes to a target specific macromolecular species, anticanine cardiac myosin antibodies, was developed. The anticanine cardiac myosin antibodies covalently coupled to liposomes were shown to retain the specific antibody activity in vitro for the homologous radioiodinated antigen. Radioisotopes can be transported inside such liposome-antibody complexes and were shown experimentally to localize in acute canine myocardial infarction. This new method of coupling of liposome to target-specific agents could provide a novel and highly specific means of transporting radioisotopes or pharmaceuticals protected within the liposomes to selected target organs.
- Subjects :
- Myocardial Infarction
Biophysics
Antigen-Antibody Complex
Myosins
Biochemistry
Antibodies
Dogs
Antigen
Animals
Molecular Biology
Liposome
biology
Chemistry
Myocardium
Antimyosin antibody
Cell Biology
Molecular biology
In vitro
Coupling (electronics)
Covalent bond
Liposomes
biology.protein
Rabbits
Antibody
Macromolecule
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....c133291a50d6050f69d44c5741712128