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Etanercept treatment-related c-ANCA-associated large vessel vasculitis

Authors :
Michael Rozenbaum
Nina Boulman
Lisa Kaly
Ofrat Katz Beyar
Itzhak Rosner
Gleb Slobodin
Doron Rimar
Shira Ginsberg
Source :
Clinical Rheumatology. 35:271-273
Publication Year :
2015
Publisher :
Springer Science and Business Media LLC, 2015.

Abstract

Anti-tumor necrosis factor (TNF) agents have become central players in the management of autoimmune and rheumatic disease. With the wide use of anti-TNF agents today, we have become aware of rare autoimmune complications as systemic lupus erythematosus and psoriasis, yet rarely has large vessels vasculitis been described. We herein describe a case of cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) (with myeloperoxidase (MPO) antibodies)-associated large vessel vasculitis (aortitis) that developed during anti-TNF treatment for ankylosing spondylitis. Awareness of this rare, but serious, adverse event of these commonly used agents in rheumatic diseases is of importance.

Details

ISSN :
14349949 and 07703198
Volume :
35
Database :
OpenAIRE
Journal :
Clinical Rheumatology
Accession number :
edsair.doi.dedup.....c12e859bb0122116ca16df56bb04ee23
Full Text :
https://doi.org/10.1007/s10067-015-3134-4