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Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
- Source :
- Radiation Oncology, Vol 14, Iss 1, Pp 1-8 (2019), Radiation Oncology (London, England)
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). Methods Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free survival (DFS). For each patient, the status of the sinus mucosa was flexibly assessed by documenting mucosal changes as indicated by differences between images obtained before radiotherapy and more than 6 months post-radiation. Results With a median follow-up of 39.7 months (8 to 81 months), 19 (8.26%) patients relapsed locally, 13 (5.65%) patients failed in the neck, and 26 (11.3%) patients developed distant metastases. The presence of sinusitis noted in images post-radiation was a significant predictor for DFS (p = 0.001), FFLF (p = 0.004), and FFDF (p = 0.015), in addition to having high negative predictive value for local relapse (97.5%). Conclusions This is the first study to investigate the prognostic value of post-radiation sinusitis in NPC patients treated with IMRT. Post-radiation sinusitis was found to be a significant predictor for DFS, FFLF, and FFDF, and was also found to have high negative predictive value for local recurrence (97.5%). It may thus be used as an additional tool for clinicians to determine the possibility of recurrence.
- Subjects :
- Male
Organs at Risk
medicine.medical_treatment
Gastroenterology
0302 clinical medicine
Recurrence
Sinusitis
Sinus (anatomy)
Aged, 80 and over
Incidence
Radiotherapy Dosage
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Predictive value
Survival Rate
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
Adult
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Post-radiation
Intensity-modulated radiation therapy
Adolescent
lcsh:R895-920
Taiwan
lcsh:RC254-282
Young Adult
03 medical and health sciences
Post-radiation sinusitis
Internal medicine
medicine
otorhinolaryngologic diseases
Nasopharyngeal carcinoma
Humans
Radiology, Nuclear Medicine and imaging
Radiation Injuries
Aged
Retrospective Studies
business.industry
Research
Local failure
Nasopharyngeal Neoplasms
medicine.disease
Radiation therapy
Radiotherapy, Intensity-Modulated
Neoplasm Recurrence, Local
business
Subjects
Details
- Language :
- English
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology
- Accession number :
- edsair.doi.dedup.....c12d99e097c84cfad0e0cb373676a402