Analytical methods for determination of bisphenol A, 4-tert-octylphenol and 4-nonylphenol in herrings and physiological fluids of the grey seal

Graphical abstract
Highlights • These methodologies have three key benefits. • Simultaneous determination of three endocrine disrupting phenol derivatives. • High sensitivity - detection by fluorescence detector. • Simply, short and not costly determination in blood and milk.
• The aim of this work was to develop the methods of determination for phenol derivatives: bisphenol A (BPA), 4-tert-octylphenol (OP) and 4-nonylphenol (NP), in the whole body of herring Clupea harengus and in physiological fluids of the Baltic grey seal Halichoerus grypus grypus (blood and milk). • Methods were based on liquid chromatography coupled with a fluorescence detector (HPLC-FL). • These methods were satisfactorily validated, each showing good recovery (>80%) and precision (RSD