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Early introduction of ESA in low risk MDS patients may delay the need for RBC transfusion: a retrospective analysis on 112 patients
- Source :
- Leukemia research. 34(11)
- Publication Year :
- 2009
-
Abstract
- ESAs are increasingly used to treat anemia of lower risk MDS, even before RBC transfusion requirement. From a previously published patient cohort treated with ESAs, we selected 112 patients with de novo low or int-1 IPSS MDS with Hb10 g/dl, serum EPO500 UI/l and who had never been transfused. Erythroid response rate at 12 weeks was 63.1% (IWG 2006). In multivariate analysis, an interval between diagnosis and ESA onset6 months, Hb level9 g/dl, and serum EPO100 UI/l predicted better response to ESA while shorter interval between diagnosis and ESA onset (p=0.01), lower serum EPO (p=0.04) and WHO diagnosis of RCMD-RS (p=0.03) were associated with longer response. Median interval from diagnosis to transfusion dependency was 80 months and 35 months, respectively, in patients with onset of ESA6 months and ≥ 6 months from diagnosis (p=0.007). Those results support early onset of ESA in lower risk MDS, to better avoid the consequences of anemia. Early introduction of ESA may also delay the need for RBC transfusions, hypothetically by slowing the disease course, but prospective studies are required to further assess this point.
- Subjects :
- Adult
Male
Risk
Cancer Research
medicine.medical_specialty
Early introduction
Anemia
Lower risk
hemic and lymphatic diseases
Internal medicine
medicine
Retrospective analysis
Humans
In patient
Darbepoetin alfa
Prospective cohort study
Erythropoietin
Aged
Retrospective Studies
Rbc transfusion
Aged, 80 and over
business.industry
Hematology
Middle Aged
medicine.disease
Recombinant Proteins
Surgery
Epoetin Alfa
Treatment Outcome
Oncology
Myelodysplastic Syndromes
Cohort
Hematinics
Female
business
Erythrocyte Transfusion
Subjects
Details
- ISSN :
- 18735835
- Volume :
- 34
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Leukemia research
- Accession number :
- edsair.doi.dedup.....c119c02b65c27b4f69f2fca391b586af