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Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes
- Source :
- Life Sciences. 59:PL387-PL390
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.
- Subjects :
- Male
Adenosine monophosphate
genetic structures
Guanine
Allopurinol
Xanthine
Cataract
General Biochemistry, Genetics and Molecular Biology
Aqueous Humor
chemistry.chemical_compound
Guanosine monophosphate
medicine
Humans
General Pharmacology, Toxicology and Pharmaceutics
Inosine
Chromatography, High Pressure Liquid
Hypoxanthine
General Medicine
eye diseases
chemistry
Biochemistry
Xanthines
Uric acid
Female
Spectrophotometry, Ultraviolet
sense organs
medicine.drug
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....c117fbc02151e1f1aaed9cff9a0fbf33