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Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group UK, 2018.
-
Abstract
- Several polymorphisms in the vitamin D receptor (VDR) are associated with the occurrence of chronic liver disease. Here, we investigated the association between BsmI, ApaI, TaqI and FokI VDR polymorphisms and the severity of liver cirrhosis in relation to serum cytokine and lipopolysaccharide binding protein (LBP) levels and their role on survival in cirrhotic patients. We found that patients harboring the BB genotype had higher MELD score, and they were mainly at CP stage C; patients harboring the AA genotype had increased LBP, IL-1β and IL-8 levels, and they were mostly at CP stage C; TT genotype carriers had higher MELD score and they were mainly at CP stage C and FF genotype carriers had lower IL-1β levels when compared to Bb/bb, Aa/aa, Tt/tt and Ff/ff genotypes respectively. In the multivariate analysis ApaI, BsmI and TaqI polymorphisms were independently associated with liver cirrhosis severity. In the survival analysis, the independent prognostic factors were CP score, MELD and the FF genotype. Our results indicate that the ApaI, TaqI and BsmI polymorphisms are associated with the severity of liver cirrhosis, through the immunoregulatory process. Survival is related to the FF genotype of FokI polymorphism, imparting a possible protective role in liver cirrhosis.
- Subjects :
- 0301 basic medicine
Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
TaqI
lcsh:Medicine
Chronic liver disease
Gastroenterology
Calcitriol receptor
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Genotype
Medicine
Humans
Vitamin D
lcsh:Science
Survival analysis
Aged
Aged, 80 and over
Multidisciplinary
biology
business.industry
Vitamin D-Binding Protein
lcsh:R
Middle Aged
medicine.disease
Prognosis
Survival Analysis
FokI
030104 developmental biology
chemistry
Gene Expression Regulation
Haplotypes
biology.protein
Cytokines
Receptors, Calcitriol
lcsh:Q
030211 gastroenterology & hepatology
Female
business
Lipopolysaccharide binding protein
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c10d4e1aeabbf433269de7233a5ad99b