Back to Search
Start Over
Clinical application of dynamic 18F-fluorodeoxyglucose positron-emission tomography / computed tomography in the differential diagnoses of musculoskeletal lesions
- Source :
- The Journal of Medical Investigation. 68(1-2):96-104
- Publication Year :
- 2021
- Publisher :
- Tokushima University Faculty of Medicine, 2021.
-
Abstract
- We aimed to assess the differential diagnostic efficacy of dynamic F-18 fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET / CT) and to evaluate the appropriate scan timings for diagnosis of musculoskeletal lesions (MSLs). Dynamic scans (5-15 [phase 1], 15-25 [phase 2], and 25-35 [phase 3] min after F-18 FDG injection) and dual-time-point scans (1 and 2 h after injection) were acquired for 23 MSLs [4 benign MSLs (BMSLs). 10 primary malignant musculoskeletal tumors (PMMSTs), and 9 metastatic musculoskeletal tumors (MMSTs)]. We compared the maximum standardized uptake values (SUVmax) and corresponding retention indices for dynamic (RI-SUVdyn) and dual-time-point (RI-SUVdual) scans and evaluated diagnostic efficacy using receiver operating characteristic (ROC) curve analyses. The SUVmax gradually decreased or was almost identical with minimal fluctuation in 3 BMSLs and 1 PMMST. SUVmax increased over time after phase 2 in 18 malignant MSLs (MMSLs). There were significant differences in SUVmax (for all time phases) and RI-SUV dual between BMSLs and MMSLs and between PMMSTs and MMSTs. In the ROC analyses, the areas under the curve for SUV in phases 2 and 3 were highest for differentiating BMSLs from MMSLs and PMMSTs from MMSTs, respectively. Dynamic F-18 FDG PET / CT is valuable for diagnosis of musculoskeletal lesions. J. Med. Invest. 68 : 96-104, February, 2021.
- Subjects :
- sarcoma
dynamic scan
Computed tomography
General Biochemistry, Genetics and Molecular Biology
Fluorodeoxyglucose positron emission tomography
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
musculoskeletal lesion
medicine
Humans
Medical diagnosis
Fluorodeoxyglucose
Dynamic Scan
Receiver operating characteristic
medicine.diagnostic_test
business.industry
bone and soft tissue tumors
General Medicine
medicine.disease
positron emission tomography computed tomography
030228 respiratory system
ROC Curve
Positron emission tomography
030220 oncology & carcinogenesis
Positron-Emission Tomography
Sarcoma
Radiopharmaceuticals
business
Nuclear medicine
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13496867
- Volume :
- 68
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- The Journal of Medical Investigation
- Accession number :
- edsair.doi.dedup.....c0e86442c024b7efe9c737b26dfa3da3