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Prostaglandin and thromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects
- Source :
- Gerontology. 32(2)
- Publication Year :
- 1986
-
Abstract
- The main cyclo-oxygenase-dependent arachidonic acid (AA) derivatives, i.e. prostaglandin E2 (PGE2) and thromboxane A2 (TXA2), have been measured by radioimmunoassay in platelet-free cultures of human monocytes from young and old subjects, in presence and in absence of activating substances (10% fetal calf serum). No difference was found between cells from the two groups as far as the production of PGE2 and TXB2 (stable metabolite of TXA2) was concerned, at variance with reported data in young and old experimental animals. The addition to the cultures of exogenous AA caused a reorientation of cyclic endoperoxide metabolism resulting in a consistent decrease of the ratio TXB2/PGE2, but only in monocytes from young subjects. The data are discussed with respect to the claimed role of prostaglandins in the age-related immune derangement which is present in aged humans.
- Subjects :
- Adult
Aging
medicine.medical_specialty
Thromboxane
Prostaglandin
Arachidonic Acids
Biology
Dinoprostone
Monocytes
chemistry.chemical_compound
Thromboxane A2
Internal medicine
medicine
Humans
Platelet
Prostaglandin E2
Cells, Cultured
Aged
Arachidonic Acid
Monocyte
Prostaglandins E
Radioimmunoassay
Middle Aged
Thromboxane B2
medicine.anatomical_structure
Endocrinology
chemistry
lipids (amino acids, peptides, and proteins)
Arachidonic acid
Geriatrics and Gerontology
medicine.drug
Subjects
Details
- ISSN :
- 0304324X
- Volume :
- 32
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gerontology
- Accession number :
- edsair.doi.dedup.....c0c86bd005f5736a351c8aea7b039e9d