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First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose
- Source :
- Biochemical Pharmacology. 98:502-510
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Exhaled breath (EB) is a promising matrix for bioanalysis of non-volatiles and has been routinely implemented for drugs of abuse analysis. Nothing is known regarding the pharmacokinetics of therapeutics and their metabolites in EB. Therefore, we used tramadol as a model drug. Twelve volunteers received a single oral dose of tramadol and repeated sampling of EB, plasma, and oral fluid (OF) was done for 48 h using a particle filter device for EB and the Quantisal-device for OF. Samples were analyzed with LC-MS/MS and the pharmacokinetic correlations between matrices were investigated. The initial tramadol half-life in EB was shorter than in plasma but it reappeared in EB after 8-24 h. The ratio of O-desmethyltramadol to tramadol was considerably lower in EB and OF compared to plasma. This pilot study compared for the first time the pharmacokinetics of a therapeutic drug and active metabolite in different biomatrices including EB and demonstrated its potential for bioanalysis.
- Subjects :
- Adult
Male
Drug
Bioanalysis
Adolescent
media_common.quotation_subject
Administration, Oral
Pharmacology
Biochemistry
Pharmacokinetics
Blood plasma
medicine
Humans
Saliva
Tramadol
Active metabolite
Aged
media_common
business.industry
Half-life
Middle Aged
O-Desmethyltramadol
Analgesics, Opioid
Breath Tests
Area Under Curve
Anesthesia
Female
business
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 00062952
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Biochemical Pharmacology
- Accession number :
- edsair.doi.dedup.....c0c6471e24208d98b1fc967aa26212c3