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Severe Dementia Predicts Weight Loss by the Time of Death
- Source :
- Frontiers in Neurology, Vol 12 (2021), Frontiers in Neurology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Background: Body mass index (BMI) in midlife is associated with dementia. However, the association between BMI and late-life obesity is controversial. Few studies have investigated the association between BMI and cognitive performance near the time of death using data from autopsy examination. We aimed to investigate the association between BMI and dementia in deceased individuals who underwent a full-body autopsy examination.Methods: Weight and height were measured before the autopsy exam. Cognitive function before death was investigated using the Clinical Dementia Rating (CDR) scale. The cross-sectional association between BMI and dementia was investigated using linear regression models adjusted for sociodemographic and clinical variables.Results: We included 1,090 individuals (mean age 69.5 ± 13.5 years old, 46% women). Most participants (56%) had a normal BMI (18.5–24.9 kg/m2), and the prevalence of dementia was 16%. Twenty-four percent of the sample had cancer, including 76 cases diagnosed only by the autopsy examination. Moderate and severe dementia were associated with lower BMI compared with participants with normal cognition in fully adjusted models (moderate: β = −1.92, 95% CI = −3.77 to −0.06, p = 0.042; severe: β = −2.91, 95% CI = −3.97 to −1.86, p < 0.001).Conclusion: BMI was associated with moderate and severe dementia in late life, but we did not find associations of BMI with less advanced dementia stages.
- Subjects :
- Aging
medicine.medical_specialty
Clinical Dementia Rating
Clinical Trials and Supportive Activities
Clinical Sciences
body mass index
Autopsy
Neurodegenerative
Alzheimer's Disease
03 medical and health sciences
0302 clinical medicine
Clinical Research
Weight loss
Internal medicine
Epidemiology
Acquired Cognitive Impairment
medicine
2.1 Biological and endogenous factors
Psychology
Dementia
Obesity
030212 general & internal medicine
Aetiology
Cognitive decline
RC346-429
Nutrition
Original Research
business.industry
aging
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
cognitive decline
medicine.disease
Brain Disorders
Neurology
Severe dementia
Neurological
epidemiology
Neurology. Diseases of the nervous system
Neurology (clinical)
weight loss
medicine.symptom
business
Body mass index
030217 neurology & neurosurgery
dementia
Subjects
Details
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....c0c2e903b99e3b9e2eb01789b6f4bdfd