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Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia
- Source :
- Metabolic Brain Disease, 34(3), 865-874. Springer
- Publication Year :
- 2019
-
Abstract
- Melatonin, a neuro-differentiation factor, may play a role in the neurodevelopmental origins of schizophrenia. Cognitive impairment and decreased melatonin are reported in schizophrenia; however, the relationship between them remains unclear. We hypothesised that patients with schizophrenia would have lower concentrations of circulating melatonin than healthy controls and that melatonin levels would be associated with cognitive impairment. This study included 47 patients with schizophrenia and 40 healthy controls (HC). Serum melatonin concentrations were measured using the enzyme-linked immunosorbent assay. Positive and Negative Syndrome Scales (PANSS), The Morningness-Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), the Stroop and Oktem verbal memory processes (VMPT) tests were applied. Patients with schizophrenia had lower levels of melatonin compared to the HC group (p = 0.016), also after controlling for age, sex, and body mass index (BMI) (p = 0.024). In patients with schizophrenia, melatonin concentrations were associated with higher BMI (rho = 0.34, p = 0.01) and lower MEQ score (rho = -0.29, p = 0.035). The patient sample was split into low and high melatonin categories by using the median melatonin concentration in HC as the cut-off. Patients in the low melatonin group had poorer performance in VMPT-Recognition (p = 0.026) and Stroop-Colour Error (p = 0.032). Notwithstanding its limitations, the findings of this exploratory study suggest that decreased serum melatonin concentrations observed in schizophrenia might also be associated with cognitive impairment and circadian preferences. Future studies are required to investigate the role of melatonergic pathways in patients with schizophrenia. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. Firat University Scientific Research Projects Management Unit Acknowledgments This work is supported with the funding from the Yeditepe University Scientific Research and Projects Unit.
- Subjects :
- Male
0301 basic medicine
VISCERAL FAT DISTRIBUTION
Verbal memory
Biochemistry
Pittsburgh Sleep Quality Index
DOUBLE-BLIND
0302 clinical medicine
Cognition
Attention
Melatonin
Middle Aged
Circadian Rhythm
Schizophrenia
Female
RHYTHM
hormones, hormone substitutes, and hormone antagonists
Circadian preferences
medicine.drug
Adult
medicine.medical_specialty
Psychosis
AGOMELATINE
PINEAL VOLUME
behavioral disciplines and activities
03 medical and health sciences
Cellular and Molecular Neuroscience
SAHBAZ C., Özer O., KURTULMUS A., KıRPıNAR I., SAHIN F., GULOKSUZ S., -Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.-, Metabolic brain disease, cilt.34, ss.865-874, 2019
Internal medicine
mental disorders
medicine
Humans
Agomelatine
Circadian rhythm
Psychiatric Status Rating Scales
Metabolic disturbance
business.industry
DRUG-FREE
Recognition, Psychology
PROFILES
NAIVE
medicine.disease
SLEEP
Melatonergic
INSOMNIA
030104 developmental biology
Endocrinology
Neurology (clinical)
business
Body mass index
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 08857490
- Database :
- OpenAIRE
- Journal :
- Metabolic Brain Disease, 34(3), 865-874. Springer
- Accession number :
- edsair.doi.dedup.....c0b66c07a9d302994556055f6f047bbf