Back to Search
Start Over
Impact of preformed donor-specific antibodies against HLA class I on kidney graft outcomes: Comparative analysis of exclusively anti-Cwvsanti-A and/or -B antibodies
- Source :
- Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos), Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação, instacron:RCAAP, World Journal of Transplantation
- Publication Year :
- 2016
- Publisher :
- Baishideng Publishing Group Inc., 2016.
-
Abstract
- AIM: To analyze the clinical impact of preformed antiHLA-Cw vs antiHLA-A and/or -B donor-specific antibodies (DSA) in kidney transplantation. METHODS: Retrospective study, comparing 12 patients transplanted with DSA exclusively antiHLA-Cw with 23 patients with preformed DSA antiHLA-A and/or B. RESULTS: One year after transplantation there were no differences in terms of acute rejection between the two groups (3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1). At one year, eGFR was not significantly different between groups (median 59 mL/min in DSA-Cw group, compared to median 51 mL/min in DSA-A-B group, P = 0.192). Moreover, kidney graft survival was similar between groups at 5-years (100% in DSA-Cw group vs 91% in DSA-A-B group, P = 0.528). The sole independent predictor of antibody mediated rejection (AMR) incidence was DSA strength (HR = 1.07 per 1000 increase in MFI, P = 0.034). AMR was associated with shortened graft survival at 5-years, with 75% and 100% grafts surviving in patients with or without AMR, respectively (Log-rank P = 0.005). CONCLUSION: Our data indicate that DSA-Cw are associated with an identical risk of AMR and impact on graft function in comparison with "classical" class I DSA. info:eu-repo/semantics/publishedVersion
- Subjects :
- 030232 urology & nephrology
Human leukocyte antigen
030230 surgery
03 medical and health sciences
0302 clinical medicine
Retrospective Cohort Study
Medicine
Transplantation
Kidney
biology
Solid-phase immunoassays
business.industry
Donor-specific antibodies
Donor specific antibodies
Panel reactive antibody
Anti human leukocyte antigen class I
Graft survival
Virology
body regions
medicine.anatomical_structure
Antibody-mediated rejection
Immunology
Antibody mediated rejection
AntiHLA-Cw antibodies
biology.protein
Antibody
business
Subjects
Details
- ISSN :
- 22203230
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- World Journal of Transplantation
- Accession number :
- edsair.doi.dedup.....c0b4236765d072ab25440bc770ce2302