SnapShot: Mammalian Rab proteins in endocytic trafficking

RAB4A,B,C (CCV, EE, RE)Endocytic recycling ZFYVE20- VPS45, RABEP1, RUFY1, GRIPAP1, AKAP10, RAB11FIP1, CD2APRAB5A,B,C EE fusion, EE biogenesis EEA1, ZFYVE20- VPS45, APPL1/2, ANKFY1, RABEP1, RABEP2, PIK3R4, PIK3CB, OCRL, INPP5B, INPP4A, F8A1, VPS8 (yeast)RAB13 (EE, TJ) RE- to- PM transport, GLUT4 traffi ckingMICALL2, MICALL1RAB21 (EE) Integrin endocytosis, cytokinesisN.D.RAB22A EE- to- Golgi transport TBC1D2B, EEA1RAB31/RAB22B (EE, TGN, PG)TGN- to- EE transport, PG maturationTBC1D2B, OCRLRAB23 (PM, EE) PG- LY fusion, Hedgehog signaling, ciliogenesisN.D.RAB35 (PM, CCV, EE)Endocytic recycling, cytokine-sis, actin dynamicsOCRL, ACAP2, FSCN1RAB3A,B,C,D (SG, SV)Regulated exocytosis (SV cycle)RPH3A, RPH3AL, RIMS1/2, RAB3IP, SYN1, SYTL4/5RAB6A,B,C (Golgi)Golgi- to- PM, Golgi- to-endosome, intra- Golgi and ER- to- Golgi transport, cytokinesisGOLGB1, GCC2, OCRL, KIF20A, MYH9, MYH10, DENND5A, BICD1, CCDC64, TMF1, APBA3, VPS52RAB8A,B (RE, G4V)TGN- to- PM transport, GLUT4 and E- cadherin traffi cking, ciliogenesis, AJ assemblyOPTN, RPH3A, MYO5B, SYTL1, MICALL2, ODF2RAB10 (TGN, G4V)TGN- to- PM transport, GLUT4 traffi cking, PG maturationMICALL1, MYO5A/B/C, RIMS1RAB11A,B (TGN, RE)Endocytic recycling, RE- to-PM transport, cytokinesis, ciliogenesis, autophagyRAB11FIP1/FIP2/FIP3/FIP4/FIP5, EXOC6, RAB3IP, ZFYVE27*, MYO5B, TBC1D14RAB25 (RAB11C) (RE)RE- to- PM transport, integrin recyclingRAB11FIP1/FIP2/FIP3/FIP4/FIP5, RAB3IP, MYO5BRAB14 (EE, TGN) Golgi- to- EE transport KIF16B, ZFYVE20, RUFY1RAB15 (EE, RE) Endocytic recycling RABIF*, REP15RAB17 (RE, ML) Endocytic recycling, ciliogen-esis, melanosome traffi ckingN.D.RAB26 (SG) Regulated exocytosis RIMS1RAB33B (Golgi, ER- Golgi and intra- Golgi transport, autophagyGOLGA2, ATG16L1, RABEP1RAB37 (Golgi, SG)Mast cell degranulation, Wnt signaling, TNF- alpha secretionRIMS1, UNC13BRAB39A, B (Golgi, PG)Phagosomal acidifi cation, IL-1 secretionCASP1RAB7A,B (LE, LY, EE- to- LE and LE- to- Golgi transport, LY biogenesisRILP, VPS35 (retromer), VPS41 (HOPS complex), PIK3R4, FYCO1RAB9A,B (LE) Endosome- to- TGN transport PLIN3, GCC2, RHOBTB3, RABEPK, SGSM2, HPS4 (BLOC- 3 complex)RAB12 (RE, LY) Transport to LY N.D.RAB27A (ML, SG) Dynamics of LRO and SG RPH3A , RPH3AL MYO5AMLPH, SYTL1- 5, UNC13D, MYRIP, CORO1CRAB32 (TV, ML, Mito, APG)Autophagy, distribution of mitochondria, traffi cking of melanogenic enzyme to MLPRKAR2A, ANKRD7RAB34 (Golgi, PM, PG)Macropinocytosis, LY positioningRILP, UNC13BRAB36 (Golgi) Spatial distribution of LE and LY RILPRAB38 (TV, ML) Transport of tyrosinase to immature MLANKRD7RAB24 (APG?) - GABARAP