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First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Male
Nuclear gene
Hemocytes
animal structures
Lineage (evolution)
Science
Zoology
010603 evolutionary biology
01 natural sciences
Article
03 medical and health sciences
Species Specificity
Neoplasms
Genotype
Animals
14. Life underwater
Genetic variation
Cancer (genus)
Cancer genetics
Phylogeny
Marine biology
Mytilus
Multidisciplinary
biology
Invasive species
Base Sequence
Host (biology)
Mytilus trossulus
fungi
Mussel
biology.organism_classification
030104 developmental biology
Biogeography
Haplotypes
1181 Ecology, evolutionary biology
Medicine
Female
Pathogens
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c0b0eeba522d3bfaebafaf32ad04a6a4