Back to Search
Start Over
The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia
The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia
- Source :
- American journal of physiology. Heart and circulatory physiology. 321(4)
- Publication Year :
- 2021
-
Abstract
- Red blood cell concentration influences the pulmonary vasculature via direct frictional force and vasoactive signaling, but whether the magnitude of the response is modified with duration of exposure is not known. By assessing the pulmonary vascular response to hemodilution in acute normobaric and prolonged hypobaric hypoxia in lowlanders and lifelong hypobaric hypoxemia in Andean natives, we demonstrated that a reduction in red cell concentration augments the vasoconstrictive effects of hypoxia in lowlanders. In high-altitude natives, hemodilution lowered pulmonary vascular resistance, but a compensatory increase in cardiac output following hemodilution rendered PASP unchanged.
- Subjects :
- Adult
Male
medicine.medical_specialty
Erythrocytes
Time Factors
Physiology
Acclimatization
Polycythemia
030204 cardiovascular system & hematology
Pulmonary Artery
Hypoxemia
03 medical and health sciences
Young Adult
0302 clinical medicine
Heart Rate
Physiology (medical)
Vasoactive
Internal medicine
Hypoxic pulmonary vasoconstriction
medicine
Humans
Arterial Pressure
Cardiac Output
Hypoxia
Hemodilution
business.industry
Altitude
Hypoxia (medical)
Middle Aged
Hemoconcentration
Blood Viscosity
Pulmonary pressure
Red blood cell
medicine.anatomical_structure
Hematocrit
Vasoconstriction
Cardiology
Vascular Resistance
Pulmonary vasculature
medicine.symptom
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15221539
- Volume :
- 321
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Accession number :
- edsair.doi.dedup.....c0ac4f9e147dadaf811aae024f99a71b