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The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

Authors :
Tony G. Dawkins
Michael M. Tymko
Connor A. Howe
Ryan L. Hoiland
Joseph Donnelly
David B. MacLeod
Jonathan P. Moore
James D. Anholm
Lydia L. Simpson
Aimee L. Drane
Philip N. Ainslie
Alexandra M. Williams
Mike Stembridge
Damian M. Bailey
Christopher Gasho
Source :
American journal of physiology. Heart and circulatory physiology. 321(4)
Publication Year :
2021

Abstract

Red blood cell concentration influences the pulmonary vasculature via direct frictional force and vasoactive signaling, but whether the magnitude of the response is modified with duration of exposure is not known. By assessing the pulmonary vascular response to hemodilution in acute normobaric and prolonged hypobaric hypoxia in lowlanders and lifelong hypobaric hypoxemia in Andean natives, we demonstrated that a reduction in red cell concentration augments the vasoconstrictive effects of hypoxia in lowlanders. In high-altitude natives, hemodilution lowered pulmonary vascular resistance, but a compensatory increase in cardiac output following hemodilution rendered PASP unchanged.

Details

ISSN :
15221539
Volume :
321
Issue :
4
Database :
OpenAIRE
Journal :
American journal of physiology. Heart and circulatory physiology
Accession number :
edsair.doi.dedup.....c0ac4f9e147dadaf811aae024f99a71b