Back to Search
Start Over
Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation
- Publication Year :
- 2017
- Publisher :
- Ferrata Storti Foundation, 2017.
-
Abstract
- To investigate cytogenetic evolution after upfront autologous stem cell transplantation for newly diagnosed myeloma we retrospectively analyzed fluorescence in situ hybridization results of 128 patients with paired bone marrow samples from the time of primary diagnosis and at relapse. High-risk cytogenetic abnormalities (deletion 17p and/or gain 1q21) occurred more frequently after relapse (odds ratio: 6.33; 95% confidence interval: 1.86-33.42; P
- Subjects :
- Oncology
Male
medicine.medical_specialty
Pathology
Multiple Myeloma/genetics
Biology
Transplantation, Autologous
03 medical and health sciences
0302 clinical medicine
Autologous stem-cell transplantation
Recurrence
Internal medicine
medicine
Internal Medicine
Autologous transplantation
Humans
Longitudinal Studies
Survival analysis
In Situ Hybridization, Fluorescence
Retrospective Studies
Chromosome Aberrations
medicine.diagnostic_test
hematology
Hazard ratio
Odds ratio
Middle Aged
Confidence interval
Transplantation
030220 oncology & carcinogenesis
Cytogenetic Analysis
oncology
Female
030215 immunology
Fluorescence in situ hybridization
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c0a1930c60c745b349027d19b7925d0f