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Dynamic states of population activity in prefrontal cortical networks of freely-moving macaque
- Source :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Neural responses in the cerebral cortex change dramatically between the ‘synchronized’ state during sleep and ‘desynchronized’ state during wakefulness. Our understanding of cortical state emerges largely from experiments performed in sensory areas of head-fixed or tethered rodents due to technical limitations of recording from larger freely-moving animals for several hours. Here, we report a system integrating wireless electrophysiology, wireless eye tracking, and real-time video analysis to examine the dynamics of population activity in a high-level, executive area – dorsolateral prefrontal cortex (dlPFC) of unrestrained monkey. This technology allows us to identify cortical substates during quiet and active wakefulness, and transitions in population activity during rest. We further show that narrow-spiking neurons exhibit stronger synchronized fluctuations in population activity than broad-spiking neurons regardless of state. Our results show that cortical state is controlled by behavioral demands and arousal by asymmetrically modulating the slow response fluctuations of local excitatory and inhibitory cell populations.<br />Authors develop an integrated wireless system to examine brain states in freely-moving monkeys. They show that neural population activity in prefrontal cortex covaries with natural behavioral dynamics. Active behavior is associated with elevated arousal and increases in spiking activity while reducing low-frequency synchrony within cortical populations.
- Subjects :
- 0301 basic medicine
Male
Science
Population
General Physics and Astronomy
Monitoring, Ambulatory
Prefrontal Cortex
Sensory system
Biology
Neural circuits
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
0302 clinical medicine
medicine
Biological neural network
Animals
Cortical Synchronization
Wakefulness
education
Prefrontal cortex
lcsh:Science
Evoked Potentials
Neurons
education.field_of_study
Multidisciplinary
Behavior, Animal
Cognitive neuroscience
Electroencephalography
General Chemistry
Macaca mulatta
Dorsolateral prefrontal cortex
Electrophysiology
030104 developmental biology
medicine.anatomical_structure
Cerebral cortex
lcsh:Q
Nerve Net
Sleep
Neuroscience
Wireless Technology
030217 neurology & neurosurgery
Locomotion
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....c09ce84b92f212024e69dae68cf586fc