Back to Search
Start Over
The Potential Protective Effect of Physalis peruviana L. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Is Mediated by Suppression of Oxidative Stress and Downregulation of MMP-9 Expression
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2014 (2014), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- The active constituent profile in Cape gooseberry (Physalis peruvianaL.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats divided into 4 groups: Group I served as control group, and Group II received weekly i.p. injection of 2 mL CCl4/kg bwt for 12 weeks. Group III were supplemented with Physalis juice via the drinking water. The animals of Group IV received Physalis juice as Group III and also were intraperitoneally injected weekly with 2 mL CCl4/kg bwt for 12 weeks. Hepatoprotective effect was evaluated by improvement in liver enzymes serum levels, reduction in collagen areas, downregulation in expression of the fibrotic marker MMP-9, reduction in the peroxidative marker malonaldehyde and the inflammatory marker nitric oxide, and restoration of the activity of antioxidant enzymatic and nonenzymatic systems, namely, glutathione content, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase activities. The results show that the potential hepatoprotective effects ofPhysalis peruvianamay be due to physalis acts by promotion of processes that restore hepatolobular architecture and through the inhibition of oxidative stress pathway.
- Subjects :
- Male
Aging
Antioxidant
Article Subject
Physalis
medicine.medical_treatment
Glutathione reductase
Down-Regulation
Pharmacology
medicine.disease_cause
Nitric Oxide
Protective Agents
Biochemistry
Superoxide dismutase
chemistry.chemical_compound
Liver Function Tests
Malondialdehyde
medicine
Animals
Rats, Wistar
lcsh:QH573-671
Carbon Tetrachloride
chemistry.chemical_classification
biology
Plant Extracts
lcsh:Cytology
Glutathione peroxidase
Cell Biology
General Medicine
Glutathione
biology.organism_classification
3. Good health
Rats
Oxidative Stress
chemistry
Liver
Matrix Metalloproteinase 9
biology.protein
Chemical and Drug Induced Liver Injury
Oxidoreductases
Oxidative stress
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19420994 and 19420900
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....c09a63c988b872b2e4a51acf9298f54c