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Classification of naturally evoked compound action potentials in peripheral nerve spatiotemporal recordings
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Peripheral neural signals have the potential to provide the necessary motor, sensory or autonomic information for robust control in many neuroprosthetic and neuromodulation applications. However, developing methods to recover information encoded in these signals is a significant challenge. We introduce the idea of using spatiotemporal signatures extracted from multi-contact nerve cuff electrode recordings to classify naturally evoked compound action potentials (CAP). 9 Long-Evan rats were implanted with a 56-channel nerve cuff on the sciatic nerve. Afferent activity was selectively evoked in the different fascicles of the sciatic nerve (tibial, peroneal, sural) using mechano-sensory stimuli. Spatiotemporal signatures of recorded CAPs were used to train three different classifiers. Performance was measured based on the classification accuracy, F1-score, and the ability to reconstruct original firing rates of neural pathways. The mean classification accuracies, for a 3-class problem, for the best performing classifier was 0.686 ± 0.126 and corresponding mean F1-score was 0.605 ± 0.212. The mean Pearson correlation coefficients between the original firing rates and estimated firing rates found for the best classifier was 0.728 ± 0.276. The proposed method demonstrates the possibility of classifying individual naturally evoked CAPs in peripheral neural signals recorded from extraneural electrodes, allowing for more precise control signals in neuroprosthetic applications.
- Subjects :
- 0301 basic medicine
Computer science
0206 medical engineering
Neural Conduction
Action Potentials
lcsh:Medicine
Sensory system
02 engineering and technology
Extraneural
Article
03 medical and health sciences
0302 clinical medicine
Peripheral nerve
Afferent
Neural Pathways
Peripheral Nervous System
Animals
Rats, Long-Evans
Nerve cuff
lcsh:Science
Electrodes
Evoked Potentials
Multidisciplinary
lcsh:R
Cuff electrode
Sciatic Nerve
020601 biomedical engineering
Rats
Peripheral
030104 developmental biology
lcsh:Q
Sciatic nerve
Biomedical engineering
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c0950bd1b60d7e7a8f6f78f75ac141c5