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T(H)1 cells control themselves by producing interleukin-10

T(H)1 cells control themselves by producing interleukin-10

Authors :
Anne O'Garra
Paulo Vieira
Division of Immunoregulation
National Institute for Medical Research
Développement des Lymphocytes
Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Source :
Nature Reviews Immunology, Nature Reviews Immunology, Nature Publishing Group, 2007, 7 (6), pp.425-8. ⟨10.1038/nri2097⟩, Nature Reviews Immunology, 2007, 7 (6), pp.425-8. ⟨10.1038/nri2097⟩
Publication Year :
2007
Publisher :
HAL CCSD, 2007.

Abstract

International audience; Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.

Details

Language :
English
ISSN :
14741741
Database :
OpenAIRE
Journal :
Nature Reviews Immunology, Nature Reviews Immunology, Nature Publishing Group, 2007, 7 (6), pp.425-8. ⟨10.1038/nri2097⟩, Nature Reviews Immunology, 2007, 7 (6), pp.425-8. ⟨10.1038/nri2097⟩
Accession number :
edsair.doi.dedup.....c089eb5bac0723395cba9d164e35cd22
Full Text :
https://doi.org/10.1038/nri2097⟩