A persistent wheeze

A 57-year-old Portuguese woman was referred to our hospital for a second opinion due to multiple respiratory infections in the previous year with a recent onset of progressive dyspnoea and wheezing. She indicated there had been no weight loss during this period. She was a former smoker of 15 pack-years who quit 20 years ago. The patient had a medical history of atrial fibrillation and breast cancer that was treated with radiotherapy. These both occurred in the same year, 5 years prior. Moreover, the patient specified that she had “asthma-like” symptoms during childhood. The patient was working as a lawyer and was medicated with bisoprolol 5 mg and montelukast 10 mg, both medications once a day. On examination, wheezes were auscultated in all lung fields, especially in the right upper lobe. Her oxygen saturation was 96% on room air and the chest radiograph revealed no abnormalities (figure 1).
What is the diagnosis of this woman with multiple respiratory infections in the previous year and a recent onset of progressive dyspnoea and wheezing? https://bit.ly/3bLgw2A