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NMDARs Translate Sequential Temporal Information into Spatial Maps
- Source :
- iScience, Vol 23, Iss 6, Pp 101130-(2020), iScience
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Summary Spatial representations of the sensory world are important for brain function. Timing is an essential component of sensory information. Many brain circuits transform the temporal sequence of input activity into spatial maps; however, the mechanisms underlying this transformation are unclear. Different N-methyl-D-aspartate receptor (NMDAR) response magnitudes result in synaptic potentiation or depression. We asked whether NMDAR response magnitude also affects the transformation of temporal information into directional spatial maps. We quantified retinotectal axon branch dynamics in Xenopus optic tectum in response to temporal sequences of visual stimulation. Reducing NMDAR responses by 50% inverts the spatial distribution of branch dynamics along the rostrocaudal axis in response to temporal patterns of input, suggesting that the magnitude of NMDAR signaling encodes the temporal sequence of inputs and translates the temporal code into a directional spatial map using structural plasticity-based branch dynamics. We discuss how this NMDAR-dependent decoding mechanism retrieves spatial information from sequential afferent activity.<br />Graphical Abstract<br />Highlights • NMDAR response magnitude encodes the temporal sequence of inputs • NMDAR mechanism decodes spatial information from sequential input activity • NMDAR attenuation inverts the temporal to spatial transformation • NMDAR activity alters the spatial distribution of dynamic and stable branches<br />Developmental Neuroscience; Sensory Neuroscience ; Techniques in Neuroscience
- Subjects :
- 0301 basic medicine
Computer science
Sensory system
02 engineering and technology
Spatial distribution
Article
Sensory neuroscience
03 medical and health sciences
Techniques in Neuroscience
Developmental Neuroscience
medicine
Axon
lcsh:Science
Spatial analysis
Multidisciplinary
Long-term potentiation
021001 nanoscience & nanotechnology
030104 developmental biology
Transformation (function)
medicine.anatomical_structure
nervous system
lcsh:Q
Spatial maps
Sensory Neuroscience
0210 nano-technology
Neuroscience
Subjects
Details
- ISSN :
- 25890042
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- iScience
- Accession number :
- edsair.doi.dedup.....c087aa0999600fc642858634b770db17