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Human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study
- Source :
- Infectious Agents and Cancer, Vol 6, Iss 1, p 9 (2011), Infectious Agents and Cancer
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Background Human papillomavirus high risk (HPV-HR) type 16 is a significant risk factor for head and neck cancers (HNC) independent of tobacco and alcohol. The purpose of this study was to determine whether antibody levels to the HPV-16 oncoproteins E6 and E7 measured in sera collected at baseline (BL) prior to treatment and at two post-treatment follow-up (FU) visits were associated with HNC risk factors or prognosis. Methods Presence of antibodies to HPV-16 E6 and E7 was evaluated in 109 newly diagnosed HNC cases with BL and FU blood samples, using the enzyme-linked immunosorbent assay (ELISA). Results HPV-16 E6 and/or E7 seropositive HNC cases were associated with higher risk in younger patients (≤ 55 years), more sexual partners (≥ 10), oropharyngeal cancer, worse stage at diagnosis, poorer grade, and nodal involvement. Between BL and FU (median = 8.3 months), there were decreased antibody levels for seropositive E6 (73% vs. 27%, p = 0.02) and seropositive E7 patients (65% vs. 35%, p = 0.09) with 5% of BL E6 and 35% of BL E7 seropositive patients converting to negative status at FU. Overall mortality (OM) was significantly worse among BL E6 seronegative patients than among BL seropositive patients (40.2% vs.13.6%, p = 0.01). There were no disease specific (DS) deaths among BL E6 seropositive vs. 24% in BL E6 seronegative patients (p = 0.01). BL E7 seronegative patients also had higher mortality than BL seropositive patients (OM: 38.2% vs. 20.0%, p = 0.04; DS: 22.5% vs. 5.6%, p = 0.07). Conclusion These findings are the first to follow post-treatment OD levels of HPV-16 E6 and E7 in HNC and suggest that these HPV antibodies may be potential prognostic markers of survival in HNC patients.
- Subjects :
- Cancer Research
medicine.medical_specialty
Epidemiology
lcsh:RC254-282
Gastroenterology
lcsh:Infectious and parasitic diseases
Serology
head and neck neoplasms
Internal medicine
medicine
lcsh:RC109-216
Human papillomavirus
human papillomavirus
Head and neck
HPV-16 E6/E7
biology
business.industry
Head and neck cancer
Case comparison
Cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Infectious Diseases
Oncology
Tropical medicine
Immunology
biology.protein
Antibody
business
Research Article
Subjects
Details
- ISSN :
- 17509378
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Infectious Agents and Cancer
- Accession number :
- edsair.doi.dedup.....c07a63af3e43abfe856bf27b07bdff97