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Butyrate enemas improve intestinal anastomotic strength in a rat model
- Source :
- Diseases of the Colon & Rectum, 53(7), 1069-1075. LIPPINCOTT WILLIAMS & WILKINS
- Publication Year :
- 2010
-
Abstract
- INTRODUCTION: Anastomotic leakage is a common clinical complication with incidences up to 10% to 17% in colorectal surgery, leading to high morbidity and mortality. Butyrate is the product of colonic fermentation of indigestible carbohydrates and is considered beneficial to gastrointestinal healing. The aim of this study was to investigate the effect of intraluminal supplementation of butyrate on colonic anastomotic strength in a rat model. METHODS: Wistar rats were randomly assigned to one of 3 groups (18 animals each). All rats underwent a 1-cm left colonic resection and end-to-end anastomosis with 4 interrupted sutures. Group I underwent no other treatment and served as the control, group II received daily 5 mL of 60 mM sodium butyrate enemas postoperatively, and group III received placebo enemas. On the third or seventh postoperative day, rats (n = 9 per time point) were anesthetized and anastomotic bursting strength was assessed. RESULTS: As a consequence of anastomotic leakage, 3 rats (16.6%) in group I, 1 rat (5.6%) in group II, and 2 rats (11.2%) in group III died. Mean anastomotic bursting pressures at day 3 were not significantly different between groups (53, 64, and 68 mm Hg for group I, II, and III, respectively, P = .777). At day 7, bursting pressures were 118, 225, and 129 mm Hg for groups I, II, and III, respectively (P = .0006). Group II showed an increased mature-to-immature collagen ratio (P = .035). CONCLUSION: Postoperative intestinal butyrate supplementation enhances anastomotic bursting strength in a left-sided partial colonic resection rat model, which can be explained by increased collagen synthesis and maturation.
- Subjects :
- Male
medicine.medical_specialty
RESECTION
LIVER
Colon
SURGERY
medicine.medical_treatment
Enema
Butyrate
Anastomotic dehiscence
Anastomosis
Placebo
Gastroenterology
chemistry.chemical_compound
LEAKAGE
Colon surgery
Internal medicine
medicine
Pressure
Animals
Rats, Wistar
Colectomy
Bursting pressure
RECTAL-CANCER
business.industry
TOTAL MESORECTAL EXCISION
Anastomosis, Surgical
Suture Techniques
Sodium butyrate
General Medicine
Colorectal surgery
Rats
Butyrates
Disease Models, Animal
CHAIN FATTY-ACIDS
chemistry
RISK-FACTORS
Rat
TRIAL
Complication
business
RADIOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 00123706
- Database :
- OpenAIRE
- Journal :
- Diseases of the Colon & Rectum, 53(7), 1069-1075. LIPPINCOTT WILLIAMS & WILKINS
- Accession number :
- edsair.doi.dedup.....c07546cc56e4328b57ea7baa58a70842